Scientific README

Project overview intended for academic and translational research audiences.

Overview

Redox Flavin is a conceptual research framework proposing adaptive redox regulation as a strategy to restore neuronal homeostasis in neurodegenerative disease.

Scientific Rationale

Mitochondrial dysfunction and impaired electron transport are frequently observed in Alzheimer’s disease.
Chronic redox drift can disrupt both energy production and redox signaling fidelity.
Static supplementation may not restore dynamic redox governance.

Core Hypothesis

Neurodegenerative redox imbalance arises, in part, from loss of intrinsic redox self-regulation. A flavin-based regulatory system may restore homeostasis by dynamically sensing and correcting redox deviations.

Conceptual Architecture (RFR)

The proposed Redoxoflavin Regulatory Protein (RFR) is a modular construct integrating:

Sensor layer: flavin-dependent redox sensing (FMN/FAD binding).
Control layer: hysteresis + integrative feedback (set-point restoration, reduced chatter).
Effector layer: activation of endogenous adaptive programs (e.g., Nrf2/ARE, PGC-1α, PINK1/Parkin).

Experimental Strategy

A staged validation roadmap is proposed (MVP-0 → MVP-4), enabling incremental verification or falsification.

White Paper Downloads

Status

Conceptual framework defined.
White paper and roadmap available.
No clinical claims; no commercial product offering.